Ask the
Doctor:
Rivka
Rachel, M.D., PhD., took her clinical
training in neurosurgery. Rivka attended
Columbia University, Center for Neurobiology
and Behavior in New York, NYAdvisor: Carol
Ann Mason, PhD, 2001, with distinction. Her
CV is both extraordinary and lengthy.
StemEnhance Questions and Answers
This page lists StemEnhance questions
from real patients and answers from Dr.
Rivka Rachel, based on knowledge of both
human physiology and adult stem cell
research, and on experience with individuals
who are taking StemEnhance. The questions
are divided into the following topics:
--How Safe Is StemEnhance?
--(How) Does StemEnhance Work?
--How Should I Take StemEnhance?
--Can StemEnhance Help Someone with a
Specific Condition?
(Questions from patients with multiple
sclerosis, amyotrophic lateral sclerosis (ALS/Lou
Gehrig's disease), Parkinson's disease,
anorexia, brain tumor, and others...)
Please note that these responses are for
information purposes only and are not
intended to substitute for medical advice.
If you have a question about StemEnhance not
addressed below that you would like to see
answered on this page, or have a question
about a specific condition that you would
like to have answered individually, please
submit it here.
(Please mention my name (Joseph Moo) if you
have any query about your health,
she will be glad to response to you promptly).
How Safe Is
StemEnhance?
StemEnhance QUESTION : I ran
into some page over the internet that claims
StemEnhance is "contaminated with
microcystins." I do not really know
what that means but they relate to all sort
of problems like cancer and more… Can you
explain this to me? Could that be true? Are
you familiar with this Dr. Peterson?
You are not the first person to come
across this exchange between Dale Peterson
and Christian Drapeau. I am not familiar
with Dr. Dale Peterson personally; all that
I know is that he could consider StemTech as
a threat to his own nutritional program or
products, and that he could have chosen more
qualified experts who would have given
different answers to some of his questions.
It is true that some types of blue-green
algae (also known as cyanobacteria or
cyanophyta for their blue-green/cyan color)
are harmful to human health because they
contain microcystins. Other types are
beneficial to human health, such as
Chlorella, Spirulina, and Aphanizomenon
flos-aquae, or AFA. [Note, however, that
AFA is the ONLY blue-green alga that
contains the stem cell-enhancing properties
of StemEnhance.] All harvesting of AFA is
subject to stringent testing to ensure that
the harvest contains pure AFA and the level
of microcystins is <1 ppm (same as <1
ug/g). You can check with the Oregon
Department of Agriculture, who oversees
harvest of AFA from Klamath Lake, the only
source of StemEnhance in the U.S.
StemEnhance QUESTION : I
understand that this Dr. Dale Peterson might
have some personal agenda against
StemEnhance, but there is an issue that is
left unanswered and it is very important,
which is the question of cancer stem cells
versus bone marrow stem cells. Aren’t they
related? Dr. Dale Peterson cites a number of
articles suggesting that normal bone
marrow-derived stem cells might contribute
to cancer. Is this true? I think this is a
very important issue that should be answered
because it appears that Christian Drapeau
did not know there is such a connection.
It is easy to cite dozens of scientific
articles (which 99.99% of people are not
going to read and/or understand) on any
topic to make the other person look like
they don't know what they are talking about.
We all have circulating bone
marrow-derived stem cells in our bodies all
the time. The simple fact of the matter is
that the empirical evidence indicates that
people with higher levels of circulating
stem cells are healthier than those with
lower levels. In fact, StemEnhance contains
a number of component molecules that have
been shown to promote health… [Part of
the answer on StemEnhance and natural
anti-tumor mechanisms has been deleted to
comply with FDA regulations.]…
This is one of those issues in science
where equally intelligent people can argue
the opposite point, and it is not until one
looks at the empirical evidence CAREFULLY,
and sometimes not until years later, that an
unequivocal answer is unanimously accepted.
Cancer is induced by mutations that
remove the normal checks and balances to
cell proliferation that are normally found
in a cell. A normal bone marrow derived
stem cell cannot cause or contribute to
cancer any more than any other normal
proliferating cell anywhere else in the
body. StemEnhance does not stimulate the
production of new stem cells, just the
release of existing stem cells from the bone
marrow. The claim that these cells will
provide a supportive environment to tumor
growth is simply not supported by the
evidence.
I will point out that all of Dale
Peterson's arguments are HYPOTHETICAL and he
cannot point to a single case of any person
who is suspected to have developed cancer
from taking StemEnhance, getting back to
your point of focusing on StemEnhance
itself.
I hope this allays your fears about tumor
growth and StemEnhance.
StemEnhance QUESTION : Did
the StemEnhance product go through any tests
and/or approval of official bodies that
concerns the public health?
Yes, there is extensive testimony as to
the safety of this particular type of
blue-green algae from the Oregon State Dept
of Agriculture. The algae grows and is
harvested from Klamath Lake in Oregon, which
is supplied by Crater Lake, the water
standard for purity in the US. If you are
interested in more information, many pages
of highly technical information are
available from the Oregon Department of
Agriculture. Also, StemEnhance has an FDA
Certificate of Free Sale, stating that it is
a safe supplement.
StemEnhance QUESTION : I
have several health issues which I am
fighting for a lot of years with no real
improvement yet. From all points of view
this product seems to be something that can
REALLY help me according to what I have read
so far, but I do not want to find myself
under more problems if this may cause some
harm - I have enough health issues already.
Although we can't predict in any given
situation how (quickly) a person will
respond, what I can tell you is that all of
the health concerns that you mention [deleted
to comply with FDA regulations] have
responded with improvement to StemEnhance in
other individuals. Some people experience a
detoxification reaction when they start
taking StemEnhance. This type of reaction
can manifest in various ways, such as a
headache or other transient symptoms. This
generally decreases over time and does not
recur. Drink plenty of water when starting,
and start slowly with 1-2 capsules daily for
several days before increasing gradually.
Because you have specific concerns, probably
4-6 capsules daily (2 x 2-3 doses) would be
ideal; however, being that cost is a concern
you can start with less and still experience
the benefit over perhaps a slower time
period. Also, some people are more sensitive
to the benefits than others and a lower dose
such as 1 capsule 2-3x daily is sufficient.
It all depends on the person.
StemEnhance QUESTION : All
this current research on adult stem cells
talks about a "transplant" of stem
cell and I don't see how this reflects on
what StemEnhance is supposed to do – is
there anything that can connect the two
(except from the fact the StemEnhance claims
to do something with Stem Cells)? If there
is, why not involving those researchers with
the StemEnhance product? (It should save the
need of a surgery or any other invasive
technique.)
This is a very good question, and perhaps
less obvious than it might appear. The
problem is both that most physicians are not
interested in natural supplements, and also
that the company is not actively trying to
set up clinical trials, for legal and
FDA-related reasons. Also, the philosophy of
the company is to keep people healthy rather
than trying to treat all these diseases
after they occur. (As a physician, I have a
little different perspective on that, since
many people are already suffering from
diseases and should also be able to
experience the benefit of SE.)
StemEnhance QUESTION : I
saw this article and am concerned about
the fact that some of the mice had more
fibrosis over time. What exactly does this
means? (Does it means the stem cell
injection is not safe?)
The experimental paradigm used in this
study was the somewhat unnatural procedure
of injecting the stem cells directly into
the muscle, which of itself could cause scar
tissue (fibrosis). By contrast, the way that
StemEnhance works is by naturally increasing
the circulation of stem cells in the
bloodstream. The question is whether, in
conditions that compromise circulation, the
enhanced circulation of stem cells induced
by SE can reach the areas of poor
circulation. I don't think the answer to
this question has been unequivocally
addressed, but it is clear that StemEnhance
benefits people with poor circulation such
as diabetes, etc. One could imagine that
over time, the enhanced function of the
endothelial (blood vessel lining) will
gradually improve and allow further access
of stem cells.
StemEnhance is just a natural way of
doing what all these other studies are
trying to do in a less natural manner by
injecting stem cells. Whether one injects
stem cells or enhances their release from
the bone marrow, both methods are aimed at
accomplishing the same purpose. It remains
to be determined over the long term whether
one method is more effective in certain
circumstances. Many people are having
significant improvements with SE, so the
empirical evidence is strong and clear.
StemEnhance QUESTION: I have
the option to start taking the product, but
I just want to be sure I am not making a
mistake (by taking some sort of a drug or
something).
Don't let the fact that StemEnhance comes
as a capsule fool you. StemEnhance is not a
drug any more than is any other whole food
that you get at the market. In some parts of
the world (for example, Africa around Lake
Chad), AFA is consumed as a dietary staple.
If you haven't yet, I suggest reading Primordial
Food, a book on the history of Aphanizomenon
flos-aquae and StemEnhance, for more
information about AFA as a food source. It
has a lot of interesting information on many
aspects of AFA and is much more readable
than some of the other articles. I also
suggest that you read through the FAQ
section of the stemtech website, which
will address in more detail some of the
questions you have raised.
I would like to let you know one more
thing about StemEnhance. I understand that
everyone has different perceptions and
expectations and understanding about stem
cells in general. If one is taking
StemEnhance as a means of maintaining
optimal health, in some ways it is less of a
momentous choice than if one is hoping that
it will aid a serious medical condition.
I honestly believe that many of the foods
that are good for health may in a small way
promote adult stem cell health, and these
effects will be discovered over time. For
now, StemEnhance is the only 'food' we have
that is known to promote adult stem cell
circulation. By looking at the algae from
which StemEnhance is derived as a food
source rather than a drug, it makes the
choice less of a giant step.
Also, while the product has been on the
market for up to two years in the US, it is
only recently that people outside of North
America are beginning to have the
opportunity to use StemEnhance. I know
plenty of people who wish this product had
been available years ago so they wouldn't
have had to suffer with their health
problems for so long.
StemEnhance QUESTION : As I
understand it, StemEnhance makes the body
release 20-30% more stem-cells from the
bone-marrow. How safe is it to make the body
do that "artificially"?--after all
if the body needed more stem cells wouldn't
it be extracting them naturally? What ill
effect will this have on the bone-marrow
itself or on the "blood stream"? I
understand that the body releases stem cells
on a natural basis, but how can you know
that making the body extract this amount
more than it naturally does will not harm
the bone marrow or the body itself? Maybe an
adult body cannot handle a larger amount of
stem cells and that is why it is being
reduced.
Everyone has circulating adult stem cells
all the time, from approximately 2-5 stem
cells/microliter of blood. StemEnhance
triggers the release of about 20-30% more
adult stem cells from the bone marrow. So
the increase in circulating stem cells is
within the physiological range. When you
consider that as people age, they have fewer
circulating stem cells, this product has the
potential to help people maintain a younger,
more optimal state of health over the long
term.
Children are very quick to get over
injuries and illnesses because their stem
cells function (in most cases) optimally. As
we age, everything slows down. It takes
longer to get over coughs and colds, longer
for cuts and scrapes to heal, eventually
longer to get out of bed in the morning.
Part of the reason for this is that our
adult stem cells are not released as
efficiently from the bone marrow. Like a car
or any other piece of equipment, over time
our bodies begin to wear out. StemEnhance is
a way to maintain optimal health over time
by maintaining optimal, i.e., like a younger
person, stem cell function.
Also, the extra stem cells that circulate
will return to the bone marrow in 4-6 hours
if they are not taken up by some other
tissue. So the question of depleting the
bone marrow is really not an issue.
StemEnhance QUESTION : To
tell the truth, I do not like the idea of
being "dependent" or
"addicted" to some kind of a drug
or supplement. How can I be sure it does not
have some addictive properties (mentally or
physically – like even some registered
drugs have)?
Also, what happens if I start taking the
StemEnhance and after a short and/or long
term use stop consuming it – what affect
will that make on the body? Can this be
harmful (after short and/or long term use)?
After stopping StemEnhance, a person's
level of circulating stem cells will be as
it was before taking the product. I haven't
heard about any withdrawal symptoms after
stopping StemEnhance, but relatively few
people stop taking it, because they
experience its long term beneficial effects.
I know plenty of people who have no
intention of ever stopping StemEnhance.
If you decide to stop taking it
temporarily, I would recommend gradually
tapering off the dose rather than
immediately stopping it. This may not be
necessary, but would address any sudden
response to the decrease in circulating stem
cells. I have not heard of addictions or
problems stopping, other than as I mentioned
some people feel so much better when taking
StemEnhance that they don't want to be
without it.
In terms of being dependent on
StemEnhance--it's like food or vitamins or
anything else that you take on a daily
basis. These are things that help us
survive, so it's not like a drug or other
potentially harmful substance that puts the
body into an artificially regulated state.
StemEnhance QUESTION : Some
of the documentation mention that the "StemEnhance"
has some component like the "phenylethylamine
(PEA), known as the "molecule of
love" or the "molecule of
joy" – can't this make a person
"high" – how can I be sure I
will not actually be consuming some sort of
a drug (even if natural) like marijuana or
something like that?
PEA is a natural component of chocolate
and other food sources. AFA is a natural
edible plant that, like spinach or broccoli
or other vegetables, happens to have
specific components that are beneficial to
human health. It is true that some people do
experience an enhanced sense of wellbeing
when taking StemEnhance--not a bad thing in
any case!
(How) Does StemEnhance Work?StemEnhance
QUESTIONS : As a person of
science, you are probably aware of the fact
that a lot of benefits that are ascribed to
dietary supplements and even to registered
drugs (mainly psychiatric ones) are due to
the placebo effect and not the result of any
real property of the product itself, while
on the other hand the side-effects of the
products were caused because of the
products. Has StemTech taken this issue
under consideration while testing and/or
documenting StemEnhance?
This is another issue that would take
pages to document and discuss. I agree this
is a possibility with anything one takes. It
is difficult to study the effects of
increasing adult stem cells in a living
human person, but from all the evidence we
have so far--hundreds of scientific journal
articles and more every day on the potential
of adult stem cells to treat many
conditions--increased numbers of circulating
stem cells are beneficial to a person's
health.
StemEnhance QUESTIONS : All
the research you mention is general research
and potential for adult stem cells. There is
no evidence that this potential can be
actually achieved by the StemEnhance powder.
A recently published scientific paper,
which is not very readable, clearly shows
the increase in circulating adult stem cells
in human volunteers taking StemEnhance (see
in particular Figure 7). While StemEnhance
has only been available for about two years,
the unconcentrated AFA alga has been on the
market for close to 30 years, which is how
the long-term stem cell-enhancing benefits
were originally discovered.
StemEnhance QUESTIONS : What
is the nutritional profile of StemEnhance?
Does the information refer to the
StemEnhance product or the Aqua plant?
The complete nutritional profile of
powdered AFA shows that this aquatic plant
contains a wide range of nutrients including
vitamins, minerals, amino acids, and fatty
acids--all important building blocks for
optimal nutrition. StemEnhance is an all
natural, 5x concentrate of the aquatic plant
Aphanizomenon flos-aquae, and one
dose of StemEnhance is 1 gram (two capsules)
of AFA powder. Keep in mind that some of the
values on the profile are per 100 grams
while others are per 1 gram, so read
carefully.
StemEnhance QUESTIONS : I am
sorry for being skeptical but it sounds like
this is a "Cure All" magic
medicine or something – too good to be
true, and that you must agree is a bit
suspicious.
Yes, of course. It is true. However,
there is nothing magical or mysterious about
how StemEnhance works, that is, about how
enhancing adult stem cell function can help
repair or regenerate damaged tissue; it is
simply human physiology. When you realize or
think about it from the viewpoint that adult
stem cells are the body's natural repair
system throughout life, it becomes less
strange to think that augmenting the
function of these cells could help a variety
of conditions and improve a person's overall
health.
StemEnhance QUESTION : If
that was true how come this product has not
been talked about in every newspaper and/or
medical paper?
It would take a few pages to even begin
to discuss the reasons for how the product
is marketed and the resistance from various
powerful groups in the US to natural
products such as StemEnhance that can help a
variety of conditions.
StemEnhance QUESTIONS : It
sounds from the "commercial" that
this is exactly what I need, but I don't
want to either throw my money away or
perhaps even cause some harm to myself by
taking something that is not fully tested
(this specific powder) and that its
influences for the long term (or even short
term) are not really known.
Again, AFA has been taken by people as a
natural whole food supplement for close to
30 years and the dramatic health
improvements experienced by a number of
people were the basis for the further
investigations of its stem cell-enhancing
properties.
I have myself been taking StemEnhance for
close to a year and have noticed many
benefits, including more energy during the
day, need for fewer hours of sleep at night,
fewer minor aches and pains, better skin
tone, brighter hair color, a resolution of
dry eyes... I could go on, but you get the
picture. And I was basically in good health
when I started taking the product.
StemEnhance QUESTIONS : Is
there anything more you can tell me that can
strengthen my belief in this product?
I would be happy to speak with you by
phone (regular or internet). Simply fill in
the contact form with your phone number, or
leave a message on either of the phone
numbers on the contact page. You may also
contact me by Skype (Skype.com) at
rivka.rachel.
StemEnhance QUESTIONS : By
the way, just to let you know - I have a
friend who has [deleted to comply with FDA
regulations] disease and takes StemEnhance.
He claims that it made a huge improvement in
his state. The improvement itself can be
seen by anyone, but who can guarantee it is
because of StemEnhance and that it is not
something temporary like a wave of some
sort?
So why don't you try it and decide for
yourself?
How Should I Take StemEnhance?StemEnhance
QUESTIONS : When I start taking
it, according to what you know so far, what
is the period of time that it takes to start
feeling the affect of the StemEnhance (days
/ weeks / months ???) and also what are the
first differences "improvements" I
should be noticing?
Each person varies with respect to the
time it takes to notice differences.
Sometimes it happens so slowly as to be
imperceptible at first. You might notice
something immediately, or it might take days
or weeks or several months. We really can't
predict for each person how they will
respond. You might feel a lot better right
away, or you might experience some 'detox'
and take a little longer to respond. The
benefits that people experience range from
little noticeable in the short term to
impressive improvements after some period of
time. The important thing is to be
consistent in taking StemEnhance until you
experience improvement.
StemEnhance QUESTIONS : I
may only be able to take the normal (as I
understood) recommended dose which is 2
capsules per day (1 morning , 1 evening). Is
that OK, or is it to little and there is no
point to start at all with such a dose?
That's fine to start with. You can try
one morning and one evening, or two in the
morning, or two in the evening. For some
people, it helps them sleep so they prefer
to take it before bedtime. For others, it
gives them a lot of energy so they don't
take it past mid-afternoon. For others it
doesn't make a difference. Your ideal dose
might be more than two capsules a day, but
you can certainly start with that and
increase as you are able.
StemEnhance QUESTIONS : Should
I consult my doctor before I start taking
it? On the one hand I want to ask someone
professional who is unbiased and knows my
condition a bit more, but on the other hand
I don't really think he will be able to give
any true professional advice regarding this
specific product, as I don't think he really
understands the areas involved. Also some
medical doctors have the tendency to
disregard natural supplements and do not
really believe in them. What do you think?
I agree it would be good to speak with
someone that knows your condition better.
However, I don't agree that most doctors are
unbiased, especially, as you say, if they
have never heard of StemEnhance and tend to
disregard natural supplements anyway.
StemEnhance QUESTIONS : Regarding
stopping StemEnhance, of course ideally if
this really helps so much, no one will want
to stop taking it, but it costs money –
and I do not know if I will always be able
to afford it (still I must be realistic).
I definitely understand that cost is an
issue for many people. At the same time, it
is not possible to put a numerical value on
good health—it is priceless. This is
important to keep in mind as well. Also, you
may also find that with time that you are
able to do much more than at present and
that cost eventually becomes less of an
issue for that reason as well.
Can
StemEnhance Help Someone with a Specific
Condition?
From a patient with multiple sclerosis:
StemEnhance QUESTIONS : What
is the recommended dose? On what time of the
day should I take the pills? morning?
evening? before/after meals?
-For MS, the recommended dose would be up
to 4 capsules 3x daily; or 2 capsules every
4 hours while awake (but see about starting
slowly, below). 'Up to' means according to
your tolerance and budget; it is not really
possible to 'overdose' on StemEnhance. If
you take them 3x/day, then morning, noon,
and evening with meals is convenient. It can
also be taken with a drink of water or
juice. However you find it works best for
you is fine. To be sure, you do not drink
any diet soda, correct? This can be very bad
for people with MS, as you probably know.
Some people experience
detoxification-type symptoms when starting,
such as a headache or flu-like symptoms,
which can be from mobilizing and getting rid
of toxins in the body. This is transient and
can usually be alleviated by starting
slowly, say, 2 capsules daily for 3 days,
then 4 capsules daily for 3 days, and so on.
StemEnhance QUESTIONS : -When
approximately should I expect an improvement
in my condition? is it a matter of weeks?
months?
Each person varies with respect to the
time it takes to notice differences.
Sometimes it happens so slowly as to be
imperceptible at first. The time to notice a
difference may depend on how long you have
been symptomatic, but again, this is only a
generalization and it could be weeks or it
could be 2-3 months. The important thing is
to be consistent in taking StemEnhance until
you experience improvement.
StemEnhance QUESTIONS : Can
StemEnhance help people after stroke? What
about Alzheimer's disease? Are there
researches or testimonies regarding these
two?
The possibility for adult stem cells to
benefit stroke and Alzheimer’s disease is
a real possibility, and animal studies of
adult stem cells in stroke have been
successful. I do not yet personally know
people with either of these conditions who
have been on StemEnhance.
StemEnhance QUESTIONS : Is
there a possibility that StemEnhance might
promote MS attacks as a result of
strengthening the immune system?
I have not heard of any cases where
StemEnhance has made MS worse. StemEnhance
actually contains phycocyanin, a potent
anti-inflammatory molecule.
StemEnhance QUESTIONS : I
have heard a story about a woman who had an
implantation of embryonic stem cells and
that caused more attacks. Have you heard
about such a case? If not, do you think such
a thing can happen?
I have not heard of such a case, but it
would make sense that introducing foreign
cells and foreign DNA could precipitate an
immune response. Also, the attack may have
been caused by contaminants in the embryonic
stem cell preparation. Neither of these
possibilities is a risk with StemEnhance
because it is your own cells and your own
DNA.
StemEnhance QUESTIONS : What
is the difference between embryonic and
adult stem cells?
Embryonic stem cells are stem cells that
exist in an embryo before birth. After
birth, these cells (even in children) are
known as adult stem cells. Adult stem cells
still retain the capacity to divide, but
they become quiescent until needed, rather
than actively and rapidly dividing as
embryonic stem cells do. The possibility
exists for embryonic stem cells to cause
abnormal cell growth. As much as we know
from research to date, this possibility does
not exist for adult stem cells. To date, all
conditions for which stem cell therapy has
proven therapeutic have been from adult stem
cells.
From a person with Parkinson's
disease:
StemEnhance QUESTIONS : - Is
it only an assumption that hematopoietic
stem cells from the bone marrow reach the
brain, or has it been proved in the lab (on
mice, etc.)?
- Why would the body need to have bone
marrow-derived stem cells in the brain if
the brain produces its own type of stem
cells? - Do these two types of SC target
different brain tissues?
- How do we know that both stem cell types
have neurogenerative and neurotrophic
capabilities?
- Do neural stem cells always remain in the
brain or could they in principle (or do
they) leave the brain in the blood stream
and reach other organs?
- StemEnhance has been shown to enhance the
release of adult stem cells to the blood
stream. Would it make sense to conjecture
that it might also enhance the release of
brain (neural) stem cells?
These are all very good questions. This
is really at the edge of what we know about
stem cells, and not all of the questions
have clear-cut answers.
First, the focus on adult stem cells from
the bone marrow is because SE specifically
releases these cells by interacting
with/inhibiting L-selectin, etc. It is not
known whether StemEnhance releases stem
cells from other tissues; this would depend
on whether they have the same molecular
signatures and same release mechanisms as
bone marrow-derived stem cells, that can
respond to the inhibitory ligand for
selectins. The reason we know that
StemEnhance increases bone marrow-derived
stem cells is because we can measure the
level of cells in the blood stream that
carry specific cell surface markers (such as
CD34 and CD133). These markers are known to
distinguish certain types of stem/progenitor
cells in the hematopoietic system.
Adult stem cells from the bone marrow,
have been shown in vitro to generate neurons
and many other types of cells; several
studies now have also injected bone
marrow-derived stem cells into mice and
shown generation of new neurons in the brain
and retina and other tissues. If you would
like specific references, let me know.
One reason, probably the major one, for
using bone marrow-derived stem cells is
their easy accessibility and relatively
larger concentration. Most other tissues are
thought to contain stem cells in very low
quantity. Because the bone marrow is
constantly generating new blood cells
throughout life, it has a very active and
relatively large (150 million cells) stem
cell population. It is also a fluid, as
opposed to solid, tissue, making
purification much easier.
The other reason, which we are just
learning, is that bone marrow-derived stem
cells have a greater potential to become
other cell types than previously recognized.
Neural stem cells from the central nervous
system are much more difficult to study and
purify, and various parts of the brain may
have different 'stem cell niches', where the
environment dictates the range of new
neurons that can be generated from stem
cells in that particular area. Adult stem
cells from the bone marrow are not subject
to this milieu effect and may therefore be
more plastic with respect to their
generative potential in the brain
(conjecture at this point).
This stem cell benefits page addresses
the question of the trophic effects of adult
stem cells in general, showing that these
cells in general have many different
beneficial effects. An excellent paper in
the American Journal of Physiology on the
acute trophic effects of bone marrow-derived
stem cells clearly explains how adult stem
cells could literally save the life of an
elderly gentleman with renal failure who had
refused dialysis and was clearly
deteriorating.
As to whether neural stem cells leave the
brain/spinal cord and travel elsewhere, I am
not aware that this happens, or that it has
specifically been addressed. Stem cells are
both unique populations based on their
ability to form specific cell types, and yet
dynamically responding to their environment,
so a stem cell in one area that carries
certain markers might change its potential
and plasticity by being in a different
environment (the whole question in
developmental biology regarding nature vs.
nurture and inflexible genetic programming
vs. environmental response--topic for
discussion another time).
From a family member of a person with
ALS (amyotrophic lateral sclerosis, also
commonly known as Lou Gehrig's disease):
StemEnhance QUESTIONS : I
have a question regarding ALS and I need
your advice. Most chances are that my father
suffers from ALS; he is having difficulty in
breathing, eating, and he lost the ability
to use his left hand. Each day it's getting
worse and the doctors refuse to give him
Rilutec.
Can Stem Enhance help him?? Can he take
it with Coumadin?
While it's not possible to predict a
response in any particular case, there is a
definite possibility that StemEnhance can
help your father. Adult stem cells have the
potential to heal and regenerate damaged
tissue from a variety of causes, and they
act through a number of repair mechanisms
rather than by just a single action.
About taking StemEnhance with Coumadin,
it is possible to do so. You should make the
doctors aware that your father plans to take
a natural supplement that contains vitamin
K, so that they know to monitor his blood
values. In this regard, StemEnhance is no
different than any other green leafy
vegetable that contains vitamin K.
StemEnhance QUESTIONS : How
can a dead cell signal that it's in trouble
(in ALS neurons are dead)?
This is a very thoughtful question. There
are several possible answers. First, damaged
cells and tissues secrete chemical signals
(called cytokines) that attract stem cells
from the blood stream to the area of injury.
These stem cells may then be able to prevent
the injured cells from dying, or could
replace the dying cells. Second, ALS or
other motor neuron diseases have two
components, the neurons and the muscle
cells. Muscle cells are dependent on trophic
signals from the nerves and will atrophy
when they do not receive neuronal input; and
likewise, nerves without attached muscles
will die as well.
So whether the additional adult stem
cells are able to regenerate neurons, which
will take a long time (neurons grow about 1
mm/day), and/or are able to halt progression
by providing trophic support to the muscles
and thereby prevent continued neuronal
death, or some other mechanism, is not
clear. The problem with ALS is that we know
too little about the causes (otherwise it
would be easier to find a cure), and so the
best thing that can be done now is to
support the body's natural repair system,
even if we don't fully understand how it
works.
NOTE: Two week follow up on this patient
with ALS: My father went for a check up and
the doctor found that his respiratory
function tests have stabilized. He feels
better and it seems like deterioration has
stopped. His left hand got a little
stronger. He is now taking 8 StemEnhance
capsules a day.
From a family member of a child with
Type I diabetes):
StemEnhance QUESTIONS : As I
understand it, the main problem of Type I
diabetes is not stem cells, but immune
system attack on the new beta cells of the
pancreas grown by the stem cells. Anyone who
is healing also has new stem cell
production. So if we could make a new immune
system or change the signature of the immune
system, or change the signature of new beta
cells then we are on the way to cure Type I
diabetes??
You are correct in noting that some
disease processes in the body are ongoing
and caused by non-stem cell related
problems. In general, there are several ways
in which StemEnhance can help, or an entire
spectrum of conditions that respond to
increased stem cell circulation in various
ways.
First is isolated conditions such as
joint damage from a one-time injury. Adult
stem cells can repair this damage over time,
and if the person stops taking StemEnhance,
the injury being permanently fixed, it will
not recur.
A semi-permanent repair may also apply on
a less complete level with, for example,
gradual changes in the retina that precede
macular degeneration, which occurs over a
long, slow term course in most people. In
these individuals, taking SE for some months
may halt or reverse the damage, which may
recur only gradually over time if they stop
taking the product.
Finally, in systemic conditions caused by
autoimmune processes, for example, taking a
product that enhances stem cell circulation
and also contains anti-inflammatory agents
can both help to regenerate new cells and
also decrease the abnormal physiological
response that caused the problem in the
first place. In such individuals, they may
need to continue enhancing adult stem cell
function over time to prevent the damage
from recurring or to keep the autoimmune
process under control. I will look for some
articles describing how stem cells can help
autoimmune conditions and send these to you
a little later.
You are also correct in assuming or
understanding that many or most conditions
are not primarily due to an adult stem cell
deficiency per se. On one hand, some people
respond to SE in such a fashion that their
primary diagnosis might well have been
'adult stem cell deficiency'. In others,
perhaps the majority of people, enhancing
adult stem cell function helps them because
stem cells are the body's natural repair and
regeneration system throughout life, and
making this system to act optimally is
simply part of a healthy lifestyle, just
like eating properly and exercising and
everything else that helps one to maintain
optimal health. To think about it this way,
it is much better to avoid disease and
maintain optimal health from the beginning,
rather than waiting until something is wrong
and trying to fix it. (Optimal health
maintenance is actually the paradigm that
StemTech advocates, rather than making
claims about trying to cure any disease in
particular. As a physician, I see things a
little differently in terms of who is most
likely to experience the most benefit from
such a product.)
That was a very long answer to a short
question, but I hope it helps address your
concerns about how a stem cell enhancer can
help a condition that is not primarily a
stem cell deficiency.
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